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Rewiring the niche: sympathetic neuropathy drives malignant niche transformation
Trevor Price1, Dorothy A Sipkins1
1Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC 27710, USA.
Abstract:
In recent years, it has become increasingly evident that hematological malignancies can alter their microenvironment, but the therapeutic implications of these changes and potential targets have not been well characterized. Recent findings now describe how sympathetic neuropathy can drive malignant transformation of the hematopoietic stem cell niche in hematopoietic malignancies.
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