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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Role of Hematopoietic Growth Factors01:28

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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microRNAs in hematopoiesis.

Seka S Lazare1, Edyta E Wojtowicz1, Leonid V Bystrykh1

  • 1Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.

Experimental Cell Research
|September 7, 2014
PubMed
Summary

MicroRNAs (miRNAs) are crucial for hematopoietic stem cell (HSC) self-renewal and blood cell differentiation. This review explores how miRNAs interact with transcription factors to regulate these vital processes.

Keywords:
HematopoiesisLineage commitmentTranscription factorsmicroRNA

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Area of Science:

  • Hematopoiesis research
  • Molecular biology
  • Stem cell biology

Background:

  • MicroRNAs (miRNAs) play a critical role in regulating gene expression.
  • Hematopoiesis, the process of blood cell formation, involves complex regulatory networks.
  • Hematopoietic stem cells (HSCs) are essential for maintaining blood cell populations throughout life.

Purpose of the Study:

  • To review the role of miRNAs in hematopoietic stem cell (HSC) maintenance.
  • To highlight the interplay between miRNAs and transcription factors in HSC differentiation.
  • To discuss various mechanisms of miRNA-mediated gene regulation in hematopoiesis.

Main Methods:

  • Literature review of studies on miRNAs in hematopoiesis.
  • Analysis of experimental data linking miRNAs to transcription factors.
  • Synthesis of information on miRNA regulatory modes.

Main Results:

  • miRNAs are integral to HSC self-renewal and differentiation into mature blood cells.
  • Significant interactions exist between specific miRNAs and transcription factors governing hematopoiesis.
  • Diverse regulatory strategies employed by miRNAs are evident in blood cell development.

Conclusions:

  • miRNAs are key regulators of hematopoietic stem cell function and blood cell production.
  • Understanding miRNA-transcription factor networks is crucial for deciphering hematopoietic regulation.
  • miRNA-based regulatory mechanisms are diverse and essential for normal hematopoiesis.