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Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study

Yoshinori Ohta1, Mio Sakuma1, Kaoru Koike2

  • 1Division of General Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care
|September 7, 2014
PubMed

Insights

Adverse drug events (ADEs) are frequent in intensive care units (ICUs) and significantly prolong patient stays. However, these events did not directly increase mortality rates in the studied population.

Area of Science:

  • Critical Care Medicine
  • Pharmacovigilance
  • Patient Safety

Background:

  • Adverse drug events (ADEs) pose a significant risk in intensive care units (ICUs).
  • Understanding the impact of ADEs on patient outcomes is crucial for improving care quality.

Purpose of the Study:

  • To determine the influence of adverse drug events (ADEs) on morbidity and mortality within intensive care units (ICUs).

Main Methods:

  • A prospective cohort study was conducted in the ICUs of three acute care hospitals in Japan.
  • Data were collected over a 6-month period from 459 adult patients (≥15 years).
  • Primary outcomes measured were ICU mortality and length of ICU stay.

Main Results:

  • The incidence of ADEs was 30.6 per 1000 patient-days, affecting 15% of patients.
  • Patients experiencing ADEs had a significantly longer median ICU stay (13 days vs. 2 days).
  • While ADEs were associated with increased ICU length of stay, they did not show a statistically significant influence on mortality after adjusting for illness severity.

Conclusions:

  • Adverse drug events are common in ICUs and are strongly linked to prolonged hospital stays.
  • The study suggests that ADEs do not significantly increase mortality in the ICU setting when accounting for patient severity.
Abstract

Keywords:
adverse drug eventsand patient safetyepidemiologyintensive care unitlength of ICU staymortality

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