Longitudinal development of left ventricular diastolic function in patients with type 2 diabetes
Laura Venskutonyte1, Christina Jarnert2, Lars Rydén2
1Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden laura.venskutonyte@ki.se.
Diabetes Care
|September 7, 2014
Summary
Left ventricular diastolic dysfunction (LVDD) in type 2 diabetes mellitus (T2DM) patients often improves or stays stable over six years. Most patients with LVDD saw their condition stabilize or resolve, indicating a favorable long-term outlook.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Background:
- Left ventricular diastolic dysfunction (LVDD) is prevalent in type 2 diabetes mellitus (T2DM).
- Longitudinal data on LVDD progression in T2DM patients without cardiovascular disease is limited.
Purpose of the Study:
- To investigate the longitudinal changes in left ventricular diastolic function (LVDF) and myocardial blood flow reserve.
- To assess the progression of LVDD in T2DM patients free from clinically evident cardiovascular disease.
Main Methods:
- Seventy-three T2DM patients (mean age 67 years) underwent LVDF assessment twice over approximately 6.4 years.
- Patients were free from clinically detectable cardiovascular disease at baseline.
Main Results:
- At baseline, 32% of patients had LVDD; 43% of these normalized LVDF during follow-up.
- Of patients with normal LVDF at baseline, 18% developed LVDD over the study period.
- Myocardial blood volume index remained stable in patients with LVDD.
Conclusions:
- The majority of T2DM patients with LVDD experienced improvement or stability in their condition over six years.
- LVDF progression in T2DM is variable, with a significant proportion showing improvement or stability.
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