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Updated: Apr 24, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
[New therapies for type 2 diabetes mellitus]
Manuel Puig-Domingo1, Silvia Pellitero1
1Servicio de Endocrinología y Nutrición, Hospital Universitari i Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Campus de Can Ruti, Badalona, Barcelona, España.
Abstract:
The increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) has led to a growing interest in the investigation of new therapies. Treatment of T2DM has focused on the insulinopenia and insulin resistance. However, in the last 10 years, new lines of research have emerged for the treatment of T2DM and preclinical studies appear promising. The possibility of using these drugs in combination with other currently available drugs will enhance the antidiabetic effect and promote weight loss with fewer side effects. The data provided by post-marketing monitoring will help us to better understand their safety profile and potential long-term effects on target organs, especially the cardiovascular risk.
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