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Estimation of the size of myocardial infarct and its clinical application
Insights
This study estimates infarct size using creatine kinase-MB (CK-MB) activity, finding a correlation with ejection fraction. Significant differences arise when myocardial necrosis affects the right ventricle.
Area of Science:
- Cardiology
- Biochemistry
- Medical Imaging
Background:
- Myocardial infarction (MI) diagnosis relies on biomarkers and imaging.
- Creatine Kinase-MB (CK-MB) is an enzyme released during heart muscle damage.
- Ejection fraction (EF) quantifies heart pump efficiency.
Purpose of the Study:
- To calculate infarct size using CK-MB activity.
- To correlate infarct size with ejection fraction.
- To assess the impact of right ventricular involvement on EF estimation.
Main Methods:
- CK-MB activity was measured in 16 patients.
- Infarct size was calculated using a proprietary computer program.
- Ejection fraction was determined via hemodynamic studies and solely from CK-MB activity changes.
Main Results:
- A significant correlation was found between infarct size and ejection fraction (p=0.01).
- Distinct differences in ejection fraction values were observed when right ventricular myocardial necrosis occurred concurrently.
- CK-MB activity provided a basis for estimating infarct size and, indirectly, ejection fraction.
Conclusions:
- CK-MB activity estimation is a viable method for calculating infarct size.
- Right ventricular involvement complicates accurate ejection fraction assessment based on CK-MB alone.
- This approach offers insights into myocardial necrosis extent and its impact on cardiac function.
Abstract:
CK-MB activity was estimated in 16 patients and infarct size was calculated on that basis using our own computer programme. The infarct size was confronted with ejection fraction calculated in haemodynamic studies (p = 0.01). In the next step the ejection fraction was determined basing exclusively on changes of CK-MB activity. Significant changes between the value of fractions defined in these ways appear in the case when myocardial necrosis simultaneously involves the right ventricle.