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Impact of BMI on cardiovascular events, renal function, and coronary artery calcification

Domenico Russo1, Luigi Francesco Morrone, Carmela Errichiello

  • 1Department of Nephrology, University of Naples 'Federico II', Naples, Italy.

Blood Purification
|September 9, 2014
PubMed

Insights

High body mass index (BMI) did not predict cardiovascular events in chronic kidney disease (CKD) patients. However, high BMI increased the risk of dialysis initiation, especially when interacting with kidney function.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Health

Background:

  • High body mass index (BMI) is a known risk factor for cardiovascular events (CVEs) in the general population.
  • The impact of BMI on CVEs and renal function decline in chronic kidney disease (CKD) patients remains controversial.
  • This study investigates the association between BMI and CVEs, dialysis initiation, and coronary artery calcification (CAC) in non-dialysis CKD patients.

Purpose of the Study:

  • To evaluate the impact of high BMI on cardiovascular events (CVEs) in CKD patients.
  • To assess the effect of high BMI on the initiation of dialysis in CKD patients.
  • To determine the relationship between high BMI and the extent and progression of coronary artery calcification (CAC) in CKD patients.

Main Methods:

  • CKD patients were stratified into normal-BMI and high-BMI groups.
  • Cardiovascular events (CVEs), dialysis initiation, and coronary artery calcification (CAC) were assessed.
  • Univariate and multivariable analyses were performed, adjusting for multiple confounding factors, with a follow-up period of 2 years or until the first event.

Main Results:

  • High BMI was not a significant predictor of CVEs in either univariate or multivariable analyses.
  • High BMI did not increase the risk for dialysis initiation in unadjusted or adjusted analyses.
  • However, an interaction between BMI and glomerular filtration rate significantly increased the risk of dialysis initiation in high-BMI patients.
  • High BMI was not associated with the extent or progression of CAC.

Conclusions:

  • High BMI is not a predictor of cardiovascular events in CKD patients.
  • High BMI is associated with an increased risk of dialysis initiation, particularly when interacting with reduced kidney function.
  • The impact of high BMI on dialysis initiation may be underestimated due to confounding factors; further research is warranted.
Abstract

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