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Updated: Apr 24, 2026
Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
Published on: October 31, 2025
Management of gastric cancer
1Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Purpose Of Review:
Gastric cancer is an uncommon cancer in the United States but is a very common cancer globally and is endemic in East Asia. It is a virulent cancer that presents with metastatic disease in about one half of United States patients.
Recent Findings:
In this review article, we discuss palliative chemotherapy options as well as validated preoperative, perioperative and postoperative strategies for locally advanced disease, which include chemotherapy and/or chemoradiation.
Summary:
In the metastatic setting, there has been incremental improvement in cytotoxic chemotherapy combinations in the past 2 decades. Two targeted agents - trastuzumab and ramucirumab - are now approved. In the locally advanced setting, perioperative chemotherapy or postoperative chemotherapy or chemoradiation improves outcomes relative to surgery alone.
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