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Updated: Feb 18, 2026

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

Published on: September 20, 2022

High-throughput discovery metabolomics.

Tobias Fuhrer¹, Nicola Zamboni¹

¹ETH Zurich, Institute of Molecular Systems Biology, Auguste-Piccard-Hof 1, 8093 Zurich, Switzerland.

Current Opinion in Biotechnology

|September 9, 2014

Summary

This summary is machine-generated.

High-throughput, non-targeted metabolomics using mass spectrometry offers broad, direct insights into cellular responses. This powerful technique is increasingly efficient for large-scale biological discovery and research.

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

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Last Updated: Feb 18, 2026

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

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Published on: September 20, 2022

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

Area of Science:

Biochemistry
Analytical Chemistry
Systems Biology

Background:

Non-targeted metabolomics, a mass spectrometry-based approach, is crucial for studying metabolic phenotypes in diverse research areas.
It offers a comprehensive view of cellular responses, requiring minimal sample preparation compared to other omics techniques.
Its suitability for large-scale screening and discovery makes it invaluable for biological research.

Purpose of the Study:

To review the current achievements and future potential of high-throughput, non-targeted metabolomics.
To highlight the capabilities of mass spectrometry in analyzing complex biological samples.
To discuss advancements driving increased throughput in metabolomic analyses.

Main Methods:

Mass spectrometry-based non-targeted metabolomics.
Review of existing literature and technological advancements.
Analysis of throughput capabilities in current metabolomic platforms.

Main Results:

Routine, precise analysis of thousands of small molecular features in thousands of samples daily is achievable.
Current high-throughput metabolomics platforms demonstrate significant analytical capacity.
Ongoing developments are poised to further enhance throughput.

Conclusions:

High-throughput, non-targeted metabolomics is a reality, enabling large-scale biological discovery.
Technological advancements, particularly in microfluidics and integrated interfaces, promise even greater efficiency.
Metabolomics continues to be a vital tool for understanding integrated cellular responses.