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Related Concept Videos

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
361
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

319
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
319
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

431
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
431
Regulation of Food Intake01:30

Regulation of Food Intake

2.8K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Updated: Apr 24, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

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Evolving directions in obesity management.

Louis J Aronne1

  • 1Weill Cornell Medical College Medical Director, Center for Weight Management and Metabolic Clinical Research, New York, NY, USA.

The Journal of Family Practice
|September 9, 2014
PubMed
Summary
This summary is machine-generated.

Obesity treatment remains challenging due to poor understanding, disease recognition issues, and limited effective options. Managing obesity is as complex as treating substance dependence, highlighting the need for better strategies.

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Area of Science:

  • Metabolic disorders
  • Public health

Background:

  • Obesity treatment has faced limitations over the last decade.
  • Incomplete understanding of obesity's pathophysiology and its recognition as a disease contribute to these challenges.
  • Safety concerns with existing medical and surgical interventions pose significant barriers.

Purpose of the Study:

  • To review the challenges in obesity treatment.
  • To highlight the need for improved understanding and therapeutic options for obesity management.

Main Methods:

  • Literature review on obesity pathophysiology and treatment efficacy.
  • Analysis of physician perspectives on obesity management challenges.

Main Results:

  • Limited efficacy of current obesity treatment options.
  • Safety concerns associated with medical and surgical obesity treatments.
  • Physician survey indicates obesity management difficulty comparable to substance dependence.

Conclusions:

  • Obesity management is complex and requires further research.
  • Enhanced understanding of obesity pathophysiology is crucial for developing effective treatments.
  • Addressing safety concerns and improving treatment efficacy are essential for better obesity care.