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Updated: Apr 24, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Anionic N-heterocyclic carbenes (NHCs): a versatile route to saturated NHCs bearing pendant weakly coordinating
Nicholas Phillips1, Rémi Tirfoin, Simon Aldridge
1Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK. simon.aldridge@chem.ox.ac.uk.
Abstract:
A versatile methodology is reported for the synthesis of anionic NHCs featuring a 5-, 6-, or 7-membered saturated heterocyclic core. Lewis acid promoted exocyclic ring closure generates systems in which the pendant borate functionality is incorporated via a CH2 linker, allowing for electronic and steric isolation of the anionic component. Hence, a library of NHCs can be accessed which incorporate metal binding environments essentially identical to the neutral parent donors, but with significantly altered solubility profiles.
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