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Noble PRST-1 Ca prostate adenocarcinoma study on noble rats: preliminary study on new androgen sensitive tumor
G Wientjes1, J Smith, R Miller
1Department of Surgery, College of Medicine, Ohio State University Columbus.
In Vivo (Athens, Greece)
|September 1, 1989
Abstract:
The Nb rat prostatic adenocarcinoma model has served as an animal model for testing various chemotherapeutic agents. Herein this preliminary report, the tumor Nb PRST-1 Ca was evaluated in 25 animals with testosterone, dihydrotestosterone, orchiectomized and control treatments. Tumor growth curves were determined and show a significant difference on day 13 (T-test) between the control group and treatment groups. Metastases were found in the lungs of all animals and a remarkable rounding of the liver was noted in the androgen treatment groups.