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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

267
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
267
Allergic Reactions02:06

Allergic Reactions

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Overview
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Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

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Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
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Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

200
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
200
Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Related Experiment Video

Updated: Apr 24, 2026

Measuring Local Anaphylaxis in Mice
07:49

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Published on: October 14, 2014

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[Anaphylaxis and anaphylactic shock].

Muriel Abi Khalil, Hassen Damak, Dumeng Décosterd

    Revue Medicale Suisse
    |September 10, 2014
    PubMed
    Summary

    Anaphylaxis, a severe allergic reaction, is often underestimated. Prompt epinephrine administration and patient education are key for managing this potentially fatal condition.

    Area of Science:

    • Allergy and Immunology
    • Emergency Medicine
    • Clinical Pathology

    Context:

    • Anaphylaxis is a critical, multisystemic circulatory issue stemming from allergic reactions.
    • Its prevalence is frequently underestimated, with reported rates between 0.05-2%.
    • Diverse etiologies contribute to anaphylaxis, varying by age and region.

    Purpose:

    • To define anaphylaxis, discuss its prevalence, etiologies, and clinical features.
    • To highlight current management strategies and preventative measures for anaphylaxis.

    Summary:

    • Anaphylaxis is an acute, severe allergic reaction causing circulatory insufficiency.
    • Clinical signs are varied due to its multisystemic nature.
    • Epinephrine injection is the primary treatment, with prevention and education being crucial.

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    Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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    Impact:

    • Emphasizes the need for increased awareness and accurate diagnosis of anaphylaxis.
    • Highlights the critical role of rapid epinephrine administration in saving lives.
    • Stresses the importance of patient education and autoinjector prescription for ongoing management and prevention.