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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Updated: Apr 24, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Reactive arthritis.

P G Stavropoulos1, E Soura, A Kanelleas

  • 11st Department of Dermatology/University Clinic, 'Andreas Syggros' Hospital, Athens, Greece.

Journal of the European Academy of Dermatology and Venereology : JEADV
|September 10, 2014
PubMed
Summary
This summary is machine-generated.

Reactive arthritis (ReA) is a post-infectious spondyloarthropathy. Its complex pathogenesis, involving genetics and immune responses, may share similarities with psoriasis.

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Area of Science:

  • Immunology
  • Rheumatology
  • Dermatology

Background:

  • Reactive arthritis (ReA) is an immune-mediated, seronegative arthritis within the spondyloarthropathy group.
  • It develops subsequent to gastrointestinal or genitourinary infections and can present with conjunctivitis, arthritis, and urethritis.
  • ReA exhibits psoriasiform dermatological manifestations and articular features similar to psoriatic arthritis, with a correlation to HLA-B27.

Purpose of the Study:

  • To explore the potential connection between Reactive arthritis and psoriasis.
  • To investigate the complex and poorly understood pathogenetic mechanisms of ReA.
  • To determine if ReA pathogenesis shares basic aspects with known psoriasis pathogenesis mechanisms.

Main Methods:

  • Literature review and analysis of existing research on Reactive arthritis and psoriasis.
  • Examination of clinical presentations, genetic factors (HLA-B27), and immunological responses (Th1/Th2 imbalance).
  • Comparison of pathogenetic pathways between ReA and psoriasis.

Main Results:

  • ReA shares clinical and genetic similarities with psoriasis, including psoriasiform skin lesions and association with HLA-B27.
  • The pathogenesis of ReA is multifactorial, involving bacterial antigenicity, host immune response (Th1/Th2 imbalance), and genetic factors.
  • A definitive link or shared pathogenetic mechanism between ReA and psoriasis remains to be fully elucidated.

Conclusions:

  • Reactive arthritis and psoriasis exhibit overlapping clinical and genetic features, suggesting a potential relationship.
  • Further research is needed to fully understand the complex pathogenesis of ReA and its potential shared mechanisms with psoriasis.
  • Investigating these connections may lead to improved diagnostic and therapeutic strategies for both conditions.