Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial dysfunction and atherosclerosis.

M A Gimbrone1

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Journal of Cardiac Surgery
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomechanical modulation of endothelial phenotype: implications for health and disease.

Handbook of experimental pharmacology·2006
Same author

Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?

Annals of the New York Academy of Sciences·2002
Same author

Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation.

The Journal of biological chemistry·2001
Same author

Argus--a new database system for Web-based analysis of multiple microarray data sets.

Genome research·2001
Same author

Ramzi S. Cotran, M.D., 1932-2000.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2001
Same author

Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism.

Arteriosclerosis, thrombosis, and vascular biology·2001

Endothelial dysfunction, a nonadaptive state of the vascular endothelium, is crucial in atherosclerosis and its thrombotic complications. Understanding endothelium

Area of Science:

  • Vascular Biology
  • Pathophysiology
  • Cardiovascular Science

Background:

  • The vascular endothelium plays a critical role in maintaining vascular health.
  • Endothelial dysfunction is implicated in the development of various vascular diseases.
  • Atherosclerosis involves complex interactions within the blood vessel wall.

Purpose of the Study:

  • To provide an overview of endothelial functions.
  • To define endothelial dysfunction.
  • To explore the link between endothelial dysfunction, atherosclerosis, and thrombosis.

Main Methods:

  • Literature review of endothelial physiology and pathology.
  • Conceptual framework development for endothelial dysfunction.
  • Analysis of mechanisms contributing to atherosclerosis and thrombotic events.

Related Experiment Videos

Main Results:

  • The endothelium is a vital functional component of the blood vessel wall.
  • Endothelial dysfunction represents a localized shift to a nonadaptive functional state.
  • This dysfunction is particularly relevant to atherosclerosis and associated thrombotic complications.

Conclusions:

  • The endothelium's active role in vascular health and disease is increasingly recognized.
  • Endothelial dysfunction is a key factor in the pathogenesis of atherosclerosis.
  • Understanding endothelial dysfunction is critical for addressing thrombotic complications in vascular disease.