Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

1.4K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.4K
Meiosis II01:57

Meiosis II

169.0K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
169.0K
Infertility in Females01:28

Infertility in Females

4.8K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
4.8K
Fertilization01:38

Fertilization

68.6K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
68.6K
Infertility in Males01:23

Infertility in Males

648
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
648

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Inclusivity of medical support in French ART centers for LGBTQIA+ patients].

Gynecologie, obstetrique, fertilite & senologie·2026
Same author

Comparison of clinical outcome after intrauterine insemination with donor semen in single women, lesbian couples and heterosexual couples.

Journal of assisted reproduction and genetics·2025
Same author

Characteristics, determinants of decision-making process and experience of French men undergoing vasectomy: a cross-sectional multicentric study.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2025
Same author

Use of tamoxifene-controlled ovarian hyperstimulation for fertility preservation before breast cancer treatment: A prospective cohort study with a 5-year follow-up.

Breast (Edinburgh, Scotland)·2024
Same author

Serum androgen dynamics in young women aged 18-40 treated with chemotherapy for breast cancer: an observational, multicentric, prospective study in France.

Human fertility (Cambridge, England)·2024
Same author

Total blastocyst usable rate is a predictor of cumulative live birth rate in IVF cycles.

Journal of gynecology obstetrics and human reproduction·2024

Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
08:06

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

1000

[Fertilization failure in IVF and ICSI].

A-S Peultier1, T Fréour1, N Cazenave2

  • 1Service de médecine et biologie de la reproduction, hôpital Mère-Enfant, CHU de Nantes, quai Moncousu, 44093 Nantes cedex 1, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|September 10, 2014
PubMed
Summary
This summary is machine-generated.

Impaired sperm parameters contribute to fertilization failure in in vitro fertilization (IVF). Oocyte quality is key in IVF with intra-cytoplasmic sperm injection (ICSI) fertilization failure.

Keywords:
FIVFertilization failureICSIIVFÉchec de fécondation

More Related Videos

A High-Throughput Method For Zebrafish Sperm Cryopreservation and In Vitro Fertilization
11:01

A High-Throughput Method For Zebrafish Sperm Cryopreservation and In Vitro Fertilization

Published on: July 6, 2009

33.9K
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
05:31

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

3.8K

Related Experiment Videos

Last Updated: Apr 24, 2026

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
08:06

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

1000
A High-Throughput Method For Zebrafish Sperm Cryopreservation and In Vitro Fertilization
11:01

A High-Throughput Method For Zebrafish Sperm Cryopreservation and In Vitro Fertilization

Published on: July 6, 2009

33.9K
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
05:31

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

3.8K

Area of Science:

  • Reproductive Medicine
  • Infertility Research
  • Assisted Reproductive Technologies

Background:

  • Fertilization failure in assisted reproductive technologies (ART) like in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) remains a clinical challenge.
  • Understanding the factors contributing to complete fertilization failure is crucial for improving ART success rates.

Purpose of the Study:

  • To investigate clinical and biological parameters associated with fertilization failure in both IVF and ICSI procedures.
  • To identify potential explanatory or predictive factors for unsuccessful fertilization in ART.

Main Methods:

  • A retrospective case-control study analyzed 1282 IVF/ICSI cycles.
  • Patients experiencing complete fertilization failure were compared to a control group with at least one embryo.

Main Results:

  • Lower antral follicle count, fewer inseminated oocytes, and reduced active sperm were significantly associated with fertilization failure in IVF (P<0.05).
  • Lower oocyte quantity and quality were significantly linked to fertilization failure in ICSI (P<0.001).
  • Logistic regression did not identify definitive explanatory or predictive factors for fertilization failure in either IVF or ICSI.

Conclusions:

  • Impaired sperm parameters are a primary factor in complete fertilization failure during conventional IVF.
  • Reduced oocyte quality is a significant contributor to fertilization failure in ICSI cycles.