Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

2.3K
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
2.3K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.8K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.8K
Extracellular Matrix01:26

Extracellular Matrix

5.8K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.8K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

1.8K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
1.8K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
The Extracellular Matrix01:42

The Extracellular Matrix

64.9K
Overview
64.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comments on the history of medical-biological studies of aging, the birth of scientific gerontology.

Current research in translational medicine·2017
Same author

Platelets, Micro-Particles and Elastase. A Review with Extrapolation to the Mechanism of Generation and Bio-Pathology of Platelet Fragments.

Pathology oncology research : POR·2017
Same author

Longevity and aging. Mechanisms and perspectives.

Pathologie-biologie·2015
Same author

Stress in biology and medicine, role in aging.

Pathologie-biologie·2015
Same author

Longevity and aging: role of genes and of the extracellular matrix.

Biogerontology·2014
Same author

Aging of connective tissues: experimental facts and theoretical considerations.

Interdisciplinary topics in gerontology·2014
Same journal

Pathologie-biologie·2020
Same journal

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie·2015
Same journal

[Not Available].

Pathologie-biologie·2015
Same journal

Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

Pathologie-biologie·2015
Same journal

Biological diagnosis of diabetes mellitus.

Pathologie-biologie·2015
Same journal

Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

Pathologie-biologie·2015
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
04:30

Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis

Published on: January 17, 2025

2.3K

Circulating elastin peptides, role in vascular pathology.

L Robert1, J Labat-Robert1

  • 1Laboratoire de recherche ophtalmologique, université Paris 5, 1, place du Parvis-Notre-Dame, 75181 Paris, France.

Pathologie-Biologie
|September 10, 2014
PubMed
Summary
This summary is machine-generated.

This study reviews the biological and pathological activities of elastin peptides. Circulating elastin peptides, identified using specific antibodies, are key to understanding atherosclerosis.

Keywords:
ElastasesElastinElastin peptidesPeptides d’élastinePharmacologie des peptides d’élastinePharmacology of elastin peptidesÉlastineκ-elastinκ-élastine

More Related Videos

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy
09:58

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy

Published on: April 9, 2018

9.6K
Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
11:46

Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D

Published on: May 19, 2018

12.1K

Related Experiment Videos

Last Updated: Apr 24, 2026

Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
04:30

Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis

Published on: January 17, 2025

2.3K
Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy
09:58

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy

Published on: April 9, 2018

9.6K
Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
11:46

Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D

Published on: May 19, 2018

12.1K

Area of Science:

  • Biochemistry
  • Pathology
  • Immunology

Background:

  • Atherosclerosis involves the degradation of elastic fibers.
  • Elastin peptides are present in circulation and possess biological properties.
  • Previous research established methods for isolating and detecting elastin peptides.

Purpose of the Study:

  • To review the biological and pathological activities of elastin peptides.
  • To highlight the significance of circulating elastin peptides in health and disease.
  • To consolidate findings on elastin peptides and their role in atherosclerosis.

Main Methods:

  • Organo-alkaline hydrolysis for isolating large elastin peptides (κ-elastin).
  • Development of specific antibodies for detecting elastin peptides and anti-elastin antibodies.
  • Quantification of elastin peptides in human blood samples.

Main Results:

  • Elastin peptides have been detected in numerous human blood samples.
  • Pharmacological properties of elastin peptides have been explored.
  • Recent studies confirm previous findings and renewed interest in circulating elastin peptides.

Conclusions:

  • Elastin peptides play a crucial role in the atherosclerotic process.
  • Circulating elastin peptides are significant biomarkers and therapeutic targets.
  • This review consolidates existing knowledge on elastin peptides' activities.