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Female breast engorgement on ranitidine--a case report
The Medical Journal of Malaysia
|December 1, 1989
Summary
A patient experienced severe bilateral breast engorgement and tenderness after taking Ranitidine for a duodenal ulcer. This side effect, a rare complication of H2 receptor antagonists, recurred upon re-administration, necessitating drug withdrawal.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Chronic duodenal ulcers often require pharmacologic management.
- Cimetidine and Ranitidine are commonly prescribed H2 receptor antagonists for acid suppression.
Observation:
- A 60-year-old woman with a chronic duodenal ulcer refractory to Cimetidine was treated with Ranitidine.
- Symptomatic improvement was noted, but accompanied by bilateral breast engorgement and tenderness.
Findings:
- The patient experienced a recurrence of severe breast engorgement and tenderness upon a second trial of Ranitidine.
- This adverse effect appeared more rapidly on rechallenge, leading to drug discontinuation.
Implications:
- This case highlights a rare but significant adverse effect of Ranitidine, specifically hyperprolactinemia-induced gynecomastia.
- The severity and recurrence on rechallenge underscore the importance of monitoring for endocrine-related side effects with H2 receptor antagonists.