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IBD: Faecal calprotectin testing--the need for better standardization.

Emanuel Burri1, Christoph Beglinger2

  • 1Department of Gastroenterology, University Medical Clinic, Cantonal Hospital, CH-4410 Liestal, Switzerland.

Nature Reviews. Gastroenterology & Hepatology
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PubMed
Summary
This summary is machine-generated.

Faecal calprotectin levels in ulcerative colitis patients vary significantly. Long-term storage of stool samples at room temperature may affect calprotectin stability, impacting disease activity assessments.

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Area of Science:

  • Gastroenterology
  • Clinical Chemistry

Background:

  • Faecal calprotectin is a key biomarker for assessing inflammatory bowel disease (IBD) activity.
  • Accurate measurement is crucial for patient management and treatment decisions.

Purpose of the Study:

  • To evaluate the variability of faecal calprotectin concentrations in patients with ulcerative colitis.
  • To investigate the stability of faecal calprotectin during room temperature storage.

Main Methods:

  • Analysis of faecal calprotectin levels in patients with mild to moderate left-sided or extensive ulcerative colitis.
  • Assessment of calprotectin concentration changes over time under room temperature storage conditions.

Main Results:

  • Significant variability observed in faecal calprotectin concentrations among patients.
  • Concerns raised regarding the long-term stability of faecal calprotectin when samples are stored at room temperature.

Conclusions:

  • Faecal calprotectin measurements in ulcerative colitis can exhibit considerable variation.
  • Current room temperature storage protocols may compromise the reliability of faecal calprotectin testing for disease activity monitoring.