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Updated: Apr 24, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population
Jianyu Han1, Jianfeng Han, Dongmei Yu
1Plastic and Cosmetic Center, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Objective:
To study the association between ADAM33 and keloid scars in the northeastern Chinese population.
Methods:
A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1 ) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results:
We observed the frequency of the rs612709 A allele exhibited a significantly decreased frequency in cases than in controls(22 vs.39.6%, P<0.0001) We also found that the frequencies of H2 (GGAAGA) haplotypes was significantly higher in the case group than in the control group (P= 0.041). In contrast, the haplotype H8 (GGGAGG) was more common in the control group than in the case group (P=0.022).
Conclusions:
Our data suggest that the ADAM33 polymorphisms may be associated with keloid scars in the northeastern Chinese population.
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