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Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
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Charcot Marie Tooth disease (CMT): historical perspectives and evolution
Mohamed Kazamel1, Christopher J Boes
1Department of Neurology, Mayo Clinic School of Graduate Medical Education, 200 First St SW, Rochester, MN, 55905, USA, kazamel.mohamed@mayo.edu.
Journal of Neurology
|September 10, 2014
Summary
Charcot-Marie-Tooth disease, a form of peroneal muscular atrophy, was first described in 1886. Historical landmarks and discoveries through the mid-20th century refined understanding of its peripheral nerve pathology.
Area of Science:
- Neurology
- Medical History
Background:
- The article traces the historical evolution of understanding peroneal muscular atrophy, a condition now known as Charcot-Marie-Tooth disease.
- It acknowledges earlier descriptions by physicians like Virchow and Eulenburg before the seminal 1886 reports.
Observation:
- Charcot and Marie initially described Progressive Muscular Atrophy, suspecting spinal cord lesions.
- Tooth later localized the pathology to peripheral nerves in his thesis.
- Dyck and Lambert's 1968 classification system categorized Charcot-Marie-Tooth disease subtypes based on inheritance, clinical course, and pathological features.
Findings:
- The historical review highlights key discoveries in understanding the peripheral nerve basis of Charcot-Marie-Tooth disease.
- It emphasizes the progression from early descriptions to detailed classification systems.
Implications:
- Understanding the historical progression of Charcot-Marie-Tooth disease research provides context for current investigations.
- This historical perspective is crucial for appreciating the diagnostic and classification advancements in neurological disorders.
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