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Juvenile idiopathic arthritis in relation to maternal prenatal smoking

Susan Shenoi1, Samantha Bell, Carol A Wallace

  • 1University of Washington School of Medicine and Seattle Children's Hospital, Seattle.

Arthritis Care & Research
|September 10, 2014
PubMed

Insights

Maternal prenatal smoking was not associated with an increased risk of juvenile idiopathic arthritis (JIA). This study found no evidence linking prenatal smoking exposure to JIA development in children.

Area of Science:

  • Pediatric Rheumatology
  • Environmental Epidemiology
  • Childhood Arthritis

Background:

  • Cigarette smoking is a known risk factor for adult rheumatoid arthritis.
  • The association between prenatal smoking and juvenile idiopathic arthritis (JIA) remains unestablished.
  • JIA is a complex condition encompassing seven distinct categories of chronic childhood inflammatory arthritis.

Purpose of the Study:

  • To investigate the relationship between maternal prenatal smoking and the incidence of JIA.
  • To examine the association between prenatal smoking and specific JIA categories.

Main Methods:

  • A case-control study involving 1,196 JIA cases and 5,618 controls identified through hospital records and birth certificates.
  • Prenatal smoking exposure was determined from birth certificates.
  • JIA was categorized using the International League of Associations for Rheumatology criteria, with adjusted odds ratios calculated via logistic regression.

Main Results:

  • No increased risk of JIA was observed in relation to maternal prenatal smoking.
  • Mothers of JIA cases reported less prenatal smoking (11%) compared to control mothers (17%).
  • A potential inverse association was noted, particularly for oligoarticular/extended oligoarticular JIA, though residual confounding by socioeconomic status cannot be excluded.

Conclusions:

  • Maternal prenatal smoking is not linked to an increased risk of developing JIA.
  • The study did not find an association between prenatal smoking and individual JIA categories.
Abstract

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