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Tissue-engineering-based strategies for regenerative endodontics.

M T P Albuquerque1, M C Valera2, M Nakashima3

  • 1Department of Restorative Dentistry, Division of Dental Biomaterials, Indiana University School of Dentistry, Indianapolis, IN 46202, USA Department of Restorative Dentistry, Division of Endodontics, Universidade Estadual Paulista, São José dos Campos Dental School, São José dos Campos, São Paulo, 12245-000, Brazil.

Journal of Dental Research
|September 10, 2014
PubMed
Summary

Tissue-engineering strategies show promise for regenerating the pulp-dentin complex in immature teeth. Bioactive nanofibrous scaffolds and stem cells are key areas of research for regenerative endodontics.

Keywords:
dental pulpdentinnanofibersregenerationstem cellstissue scaffolds

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Endodontics

Background:

  • Tissue-engineering strategies offer potential for pulp-dentin complex regeneration, especially in immature necrotic teeth.
  • Nanofibrous scaffolds, mimicking the extracellular matrix, are synthesized via techniques like electrospinning.
  • Scaffold design incorporates biochemical and physical cues to guide cellular activity and tissue development.

Purpose of the Study:

  • To provide a comprehensive review of recent advancements in scaffolds and stem cells for regenerative endodontics.
  • To focus on bioactive nanofibrous scaffolds, injectable scaffolds, stem cells, and pre-clinical findings.
  • To discuss future directions and potential clinical translation of these regenerative strategies.

Main Methods:

  • Review of in vitro and in vivo pre-clinical studies.
  • Analysis of tissue-engineering-based strategies for pulp-dentin regeneration.
  • Focus on bioactive nanofibrous scaffolds, injectable scaffolds, and stem cell applications.

Main Results:

  • Nanofibrous scaffolds show regenerative potential in vitro and in vivo (subcutaneous models).
  • Bioactive molecules can be locally delivered via scaffolds, enhancing clinical possibilities.
  • No single scaffold currently guides the complete, coordinated regeneration of the pulp-dentin complex.

Conclusions:

  • Scaffolds and stem cells hold significant promise for regenerative endodontics.
  • Further research is needed to develop scaffolds that can guide coordinated tissue growth for functional regeneration.
  • Potential applications include dentin and pulp regeneration, and root canal disinfection.