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A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer
Naoya Murakami1, Hiroyuki Okamoto2, Takahiro Kasamatsu3
1Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan ore-murakami@hotmail.co.jp.
Background/Aim:
The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity.
Patients And Methods:
Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared.
Results:
Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V30Gy, V50Gy; bladder V45Gy, V50Gy; Bowel V35Gy, and V50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V10Gy, V30Gy, and V40Gy of BMS-IMRT were statistically lower than that of normal-IMRT.
Conclusion:
Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.
