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Updated: Apr 24, 2026

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
Migration of intraocular silicone oil from the vitreous cavity into the upper eyelid causing ptosis
Yuzo Deguchi1, Takatoshi Maeno1, Yuichi Hori1
1Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Tochigi, Japan.
Introduction:
To report a case in which intraocular silicone oil migrated into the upper eyelid and caused ptosis.
Methods:
A 65-year-old woman presented with proliferative vitreoretinopathy in the right eye. Vitrectomies, injection of silicone oil and encircling were performed. Two months after the last operation, swelling of her right eyelid occurred.
Result:
Magnetic resonance imaging revealed moisture in the palpebral fat tissue. We incised the bulbar conjunctiva and confirmed silicone oil leakage from the vitreous cavity through the scleral button hole of the encircling suture. Postoperatively, the right upper eyelid swelling decreased. Histopathologically, dense macrophage infiltration was seen in the palpebral tissues.
Conclusions:
We report a rare case with a postoperative complication caused by silicone oil. In cases with swelling of the eyelid and decreased silicon oil in the vitreous cavity postoperatively, clinicians should consider the possibility of silicone oil leakage.
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