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Increased frequency of Mediterranean fever gene variants in multiple myeloma

Serkan Celik1, Fatih Tangi2, Cagatay Oktenli3

  • 1Division of Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey.

Oncology Letters
|September 10, 2014
PubMed

Insights

Inherited variants in the Mediterranean fever (MEFV) gene are more common in multiple myeloma (MM) patients than controls. This suggests the MEFV gene may increase cancer susceptibility.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Multiple myeloma (MM) is a hematological malignancy.
  • The Mediterranean fever (MEFV) gene is associated with autoinflammatory diseases.
  • Previous studies suggest a potential link between MEFV variants and other conditions.

Purpose of the Study:

  • To investigate the frequency of inherited variants in the MEFV gene among multiple myeloma patients.
  • To compare MEFV variant frequencies between MM patients and healthy controls.
  • To explore the potential role of the MEFV gene in cancer susceptibility.

Main Methods:

  • A pilot study comparing 28 MM patients and 65 healthy controls.
  • Genotyping for inherited variants in the MEFV gene.
  • Statistical analysis (Chi-squared test) to compare variant frequencies.

Main Results:

  • Six heterozygous and one homozygous (E148Q/E148Q) MEFV variant identified in MM patients.
  • Eleven heterozygous MEFV variants found in the healthy control group.
  • A statistically significant higher frequency of MEFV variants in MM patients compared to controls (P=0.027).

Conclusions:

  • Inherited variants in the MEFV gene are significantly more frequent in multiple myeloma patients.
  • The MEFV gene is hypothesized to be a cancer susceptibility gene.
  • Further research, including familial aggregation and animal models, is needed to confirm this hypothesis.
Keywords:
MEFV geneinterleukin-1βmultiple myelomanuclear factor-κB

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