Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

1.1K
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
1.1K
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

984
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
984
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.2K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Dexmedetomidine Treatment After Cerebral Ischemia/Reperfusion on Apoptosis and Oxidative Stress: A Rat Model.

Life (Basel, Switzerland)·2026
Same author

An unexpected threat in the heart: Hydatid cyst in the interventricular septum.

Turk gogus kalp damar cerrahisi dergisi·2026
Same author

Comparison of Ultrasound-Guided Quadratus Lumborum Plane Block and External Oblique Intercostal Plane Block for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Two-Center Randomized Controlled Trial.

Medicina (Kaunas, Lithuania)·2025
Same author

Anesthesia Management in a Crisponi Syndrome Patient Undergoing Tracheotomy Surgery.

Case reports in pediatrics·2025
Same author

Vision Transformers-Based Deep Feature Generation Framework for Hydatid Cyst Classification in Computed Tomography Images.

Journal of imaging informatics in medicine·2025
Same author

Ultrasound-Guided Regional Anesthesia in Permanent Pacemaker Implantation: An Observational Study.

Medicina (Kaunas, Lithuania)·2025

Related Experiment Video

Updated: Apr 24, 2026

A Teleoperated Robotic System-Assisted Percutaneous Transiliac-Transsacral Screw Fixation Technique
05:57

A Teleoperated Robotic System-Assisted Percutaneous Transiliac-Transsacral Screw Fixation Technique

Published on: January 6, 2023

3.2K

A miracle that accelerates operating room functionality: sugammadex.

Erdal Dogan1, Mehmet Salim Akdemir2, Abdulmenap Guzel1

  • 1Department of Anesthesiology and Reanimation, Faculty of Medicine, Dicle University Medical School, Diyarbakir, Turkey.

Biomed Research International
|September 10, 2014
PubMed
Summary

Sugammadex effectively reversed residual neuromuscular block when neostigmine failed, achieving adequate recovery and extubation rapidly with no observed side effects. This offers a safe alternative for decurarisation.

More Related Videos

C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position
12:25

C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position

Published on: September 16, 2022

3.8K
Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

10.9K

Related Experiment Videos

Last Updated: Apr 24, 2026

A Teleoperated Robotic System-Assisted Percutaneous Transiliac-Transsacral Screw Fixation Technique
05:57

A Teleoperated Robotic System-Assisted Percutaneous Transiliac-Transsacral Screw Fixation Technique

Published on: January 6, 2023

3.2K
C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position
12:25

C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position

Published on: September 16, 2022

3.8K
Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

10.9K

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Sugammadex is a modified cyclodextrin designed for rocuronium and vecuronium.
  • It presents an alternative to cholinesterase inhibitors for neuromuscular block reversal.

Purpose of the Study:

  • To investigate the efficacy of sugammadex in reversing neuromuscular block.
  • To evaluate sugammadex as a rescue therapy after insufficient decurarisation with neostigmine.

Main Methods:

  • A study involving 14 patients with insufficient decurarisation (TOF <0.9) after neostigmine.
  • Administration of 2 mg/kg sugammadex following inadequate neostigmine reversal.
  • Data collected on time to TOF ≥0.9 and extubation time.

Main Results:

  • Sugammadex administration led to a TOF ratio ≥0.9 in 2.1 ± 0.9 minutes.
  • Extubation was achieved 3.2 ± 1.4 minutes after sugammadex administration.
  • No significant hemodynamic changes or adverse events were noted post-sugammadex administration.

Conclusions:

  • Sugammadex is effective in reversing rocuronium-induced neuromuscular block.
  • It serves as a successful rescue treatment when neostigmine provides insufficient decurarisation.
  • The study highlights sugammadex's safety and rapid efficacy in this clinical scenario.