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Drug cutaneous side effect: focus on skin ulceration.

S D'Epiro1, M Salvi1, A Luzi1

  • 1Department of Dermatology and Venereology, Policlinico "Umberto I", "Sapienza" University of Rome, Italy.

La Clinica Terapeutica
|September 10, 2014
PubMed
Summary

Drug-induced skin ulcers, often linked to chemotherapy and targeted therapies, present a significant clinical challenge. Early recognition and considering these agents as a differential diagnosis are crucial for effective patient management.

Keywords:
drugside effectsskinulceration

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Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Skin ulcers involve deep tissue loss with poor healing, causing pain, infection risk, and economic burden.
  • Vascular disease, infections, tumors, and autoimmunity are common causes, but drug-induced ulceration is increasingly recognized.

Purpose of the Study:

  • To highlight the role of antineoplastic agents in causing skin ulceration.
  • To emphasize the importance of considering drug-induced ulcers in cancer patients.

Main Methods:

  • Literature review of drug-induced skin ulceration cases.
  • Analysis of evidence linking specific therapies to ulcer development.

Main Results:

  • Chemotherapy agents and molecular targeted therapies are frequently implicated in drug-induced skin ulcers.
  • Evidence includes delayed onset, improvement upon drug withdrawal, and recurrence upon reintroduction.

Conclusions:

  • Antineoplastic agents should be considered a differential diagnosis for skin ulcers in cancer patients.
  • Patients with comorbidities undergoing these therapies require particular attention for this adverse effect.