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[Reported drug allergy among children attending day care centers]
Pedro Martins1, Joana Belo2, João Marques2
1Centro de Estudos de Doenças Crónicas. Faculdade de Ciências Médicas. Universidade Nova de Lisboa. & Serviço de Imunoalergologia. Hospital de Dona Estefânia. Centro Hospitalar Lisboa Central. & Centro de Investigação. Hospital de Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa. Portugal.
Insights
Parent-reported drug allergy prevalence in young children is significant, affecting 4.1% of those in daycare. Factors like age and food allergies increase risk, while higher parental education may decrease it.
Area of Science:
- Pediatric Allergy and Immunology
- Epidemiology
- Environmental Health
Context:
- Limited data exists on drug allergy prevalence in children.
- Daycare centers provide a unique setting for pediatric health studies.
- The ENVIRH study investigated environmental factors and child health.
Purpose:
- To estimate the prevalence of parent-reported drug allergy in children attending daycare in Lisbon and Oporto.
- To identify factors associated with drug allergy in this pediatric population.
Summary:
- A health questionnaire was administered to 1,169 children (mean age 3.5 years) in daycare centers.
- The prevalence of reported drug allergy was 4.1% (95% CI: 3.0–5.2%), with antibiotics and NSAIDs most frequently implicated.
- Drug allergy was associated with increased age, co-reported food allergy, and inversely with parental education level.
Impact:
- Findings suggest a notable prevalence of reported drug allergy in preschool-aged children.
- Highlights the need for accurate drug allergy assessment to prevent unnecessary drug avoidance.
- Provides data for public health initiatives and clinical practice guidelines in pediatric allergy.
Introduction:
Data about drug allergy prevalence in the general population, particularly in children, are lacking. This study aimed to estimate the prevalence of parent-reported drug allergy, in children attending day care centers in Lisbon and Oporto.
Material And Methods:
In Phase II of the "ENVIRH study - Environment and Health in Children Day Care Centers", a health questionnaire which included questions about drug allergies was administered to children by stratified, random sampling of day care centers.
Results:
The final analysis included 1,169 questionnaires, 52.5% from boys. The mean age was 3.5 ± 1.5 years. The prevalence of reported drug allergy was 4.1% (95% CI: 3.0 - 5.2%). The most frequently reported drugs were antibiotics (27 cases) and NSAIDs (in 6 cases). In the multivariate analysis, reported drug allergy was directly associated with age (OR 1.19; 95% CI 1.01 - 1.41) and reported food allergy (OR 3.19; 95% CI 1.41 - 7.19). It was inversely associated with the level of parental education (OR 0.25; 95% CI 0.10 - 0.59).
Discussion:
Even though the limitations of the study our results are in accordance with those reported by previous authors and suggest that there is a high prevalence of reported drug allergy in the considered age group.
Conclusion:
A correct assessment of these situations is needed in order to avoid unnecessary drug evictions.
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