Related Experiment Video

Updated: Apr 24, 2026

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
18:46

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

13.9K

[Study on preparation of andrographolide composite particles based on mechanical crushing method and its dissolution]

Xiao-Ping Wang, Li Han, Gui-Lin Ren

    Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
    |September 11, 2014
    PubMed
    Summary

    This study developed andrographolide composite particles using mechanical crushing. These particles significantly improved the dissolution rate of andrographolide compared to raw materials and physical mixtures.

    More Related Videos

    Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering12:22

    Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

    Published on: October 26, 2016

    11.3K
    Facile Preparation of Ultrafine Aluminum Hydroxide Particles with or without Mesoporous MCM-41 in Ambient Environments05:50

    Facile Preparation of Ultrafine Aluminum Hydroxide Particles with or without Mesoporous MCM-41 in Ambient Environments

    Published on: May 11, 2017

    10.2K

    Related Concept Videos

    Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

    Factors Affecting Dissolution: Particle Size and Effective Surface Area

    Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
    1.9K
    Colloidal precipitates01:09

    Colloidal precipitates

    The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
    5.7K
    Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

    Factors Influencing Drug Absorption: Pharmaceutical Parameters

    Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
    827
    In Vitro Drug Dissolution: Compendial Testing Models I01:13

    In Vitro Drug Dissolution: Compendial Testing Models I

    Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
    546
    In Vitro Drug Dissolution: Alternative Methods01:17

    In Vitro Drug Dissolution: Alternative Methods

    Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
    376