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[Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats]
Objective:
To investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.
Method:
Window craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.
Result:
Zige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.
Conclusion:
Zige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.
