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Updated: Apr 24, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Gut microbiome and multiple sclerosis
Pavan Bhargava1, Ellen M Mowry
1Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Pathology 627, Baltimore, MD, 21287, USA, pbharga2@jhmi.edu.
Abstract:
The commensal flora that lives in the human gut is a unique ecosystem that has evolved over millennia with human beings. The importance of the microbiota in various bodily functions is gradually becoming more apparent. Besides the gut microbiome playing a role in bowel-related disorders, a role in metabolic and autoimmune disorders is becoming clearer. The gut bacteria play a role in educating the immune system and hence may be a player in the development of multiple sclerosis. We examine the different sources of information linking the gut microbiota to multiple sclerosis and examine the future avenues for utilizing the knowledge of the gut microbiome to potentially treat and prevent multiple sclerosis.
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