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Theophylline disturbs sleep mainly in caffeine-sensitive persons
C Janson1, T Gislason, M Almqvist
1Department of Lung Medicine, Uppsala University, Sweden.
Pulmonary Pharmacology
|January 1, 1989
Summary
Theophylline disturbed sleep primarily in caffeine-sensitive individuals. Caffeine-insensitive persons showed no sleep disturbances when taking theophylline versus placebo.
Area of Science:
- Pharmacology
- Sleep Medicine
- Clinical Trials
Background:
- Theophylline is a medication with potential effects on sleep.
- Individual sensitivity to stimulants like caffeine may influence responses to theophylline.
- Understanding theophylline's impact on sleep is crucial for patient care.
Purpose of the Study:
- To investigate the effects of slow-release theophylline on sleep patterns.
- To determine if caffeine sensitivity influences theophylline's impact on sleep.
Main Methods:
- A randomized, double-blind, cross-over study design was employed.
- 13 healthy male volunteers participated, categorized by caffeine sensitivity.
- Sleep was assessed using diaries, questionnaires, and sleep recordings over two-week periods.
Main Results:
- Caffeine-sensitive individuals reported sleep disturbances with theophylline.
- Sleep latency increased and sleep efficiency decreased in caffeine-sensitive participants on theophylline.
- Caffeine-insensitive participants experienced no significant sleep changes.
Conclusions:
- Theophylline appears to disrupt sleep predominantly in individuals sensitive to caffeine.
- Caffeine sensitivity is a key factor in predicting theophylline's sleep-related side effects.