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Updated: Apr 24, 2026
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Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
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Inflammatory monocyte effector mechanisms
Grégoire Lauvau1, Laurent Chorro1, Emily Spaulding1
1Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA.
Cellular Immunology
|September 11, 2014
Summary
Inflammatory monocytes, crucial for innate immunity, exhibit remarkable functional plasticity. These cells play diverse roles in fighting microbial infections, acting as antigen-presenting, inflammatory, or Trojan horse cells.
Area of Science:
- Immunology
- Cell Biology
Background:
- Monocytes are essential blood-derived phagocytic cells involved in innate immune responses.
- Inflammatory monocytes (Ly6C(+) CCR2(+)) are the predominant subset in mice, analogous to human CD14(+) monocytes.
Purpose of the Study:
- To review the functional plasticity of inflammatory monocytes.
- To explore their diverse in vivo roles during host defense against microbial pathogens.
Main Methods:
- Review of published evidence on monocyte function and roles in infection.
Main Results:
- Monocytes display significant functional plasticity.
- These cells act as antigen-presenting cells, inflammatory cells, and Trojan horse cells during infections.
Conclusions:
- Inflammatory monocytes are highly adaptable immune cells.
- Their multifaceted roles are critical for effective host defense against microbial pathogens.
Keywords:
Antigen presentationCCR2Effector functionsInflammatory Ly6C(+) monocytesMicrobial pathogensMore Related Videos
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