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A journey to the total synthesis of daptomycin
Hiu Yung Lam1, Rannveig Ingebrigtsen Gaarden, Xuechen Li
1Department of Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.
Chemical Record (New York, N.Y.)
|September 11, 2014
Abstract:
Daptomycin, the first antibiotic of its class, provides a new structural motif for the development of new antibiotics. Recently, we have completed the total synthesis of daptomycin. The development of the successful synthetic strategy is described here, including the application of serine/threonine ligation mediated peptide cyclization to the daptomycin macrocyclization.