Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Setting up an HIV screening program.

A Williams1, R Y Dodd

  • 1American Red Cross, Jerome H. Holland Laboratory, Rockville, MD 20855.

Transfusion Medicine Reviews
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myocardial abscess: an unusual complication of long-term hemodialysis line presence.

Clinical nephrology·1999
Same author

"One-stop" surgery: implications for anesthesiologists of an expedited pediatric surgical process.

Southern medical journal·1999
Same author

Calculating the global burden of disease: time for a strategic reappraisal?

Health economics·1999
Same author

Aerosol route enhances the contamination of intact eggs and muscle of experimentally infected laying hens by Salmonella typhimurium DT104.

FEMS microbiology letters·1999
Same author

Short gastric artery perforation after use of 'ecstasy'.

Journal of the Royal Society of Medicine·1999
Same author

Meniscal movement. An in-vivo study using dynamic MRI.

The Journal of bone and joint surgery. British volume·1999
Same journal

Assessment of CTLA-4, LAG-3, and TIM-3 Expression in Pediatric Patients With β-Thalassemia Major and Their Association With Alloimmunization.

Transfusion medicine reviews·2026
Same journal

A Reply to "Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine".

Transfusion medicine reviews·2026
Same journal

Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine.

Transfusion medicine reviews·2026
Same journal

Trust Over Knowledge: Rethinking Donor Iron Supplementation Strategies in Modern Blood Services-Authors' reply.

Transfusion medicine reviews·2026
Same journal

The Effect of Stress Ball and Music on Anxiety, Distress, and Pain Levels During Platelet Apheresis Donation: Randomized Controlled Trial.

Transfusion medicine reviews·2026
Same journal

Therapeutic Plateletpheresis for Thrombocytosis: Critical Analytic Reviews and Original Multicenter Experience.

Transfusion medicine reviews·2026
See all related articles

Establishing effective human immunodeficiency virus-1 (HIV-1) screening programs requires careful consideration of test performance, cost, and ethical factors. Current enzyme immunoassay (EIA) screening with Western blot confirmation accurately identifies most HIV-1 cases, with indeterminate results resolvable by further testing.

Area of Science:

  • Clinical diagnostics and infectious disease screening.
  • Public health and epidemiology of viral infections.

Background:

  • Current human immunodeficiency virus-1 (HIV-1) screening relies on enzyme immunoassay (EIA) detecting specific antibodies, followed by confirmatory testing.
  • Effective screening programs necessitate evaluation of performance, cost, confidentiality, legal aspects, quality control, and laboratory safety.

Purpose of the Study:

  • To outline key considerations for establishing robust HIV-1 screening programs.
  • To discuss the performance and limitations of current diagnostic assays for HIV-1 detection.

Main Methods:

  • Review of current HIV-1 screening protocols, including enzyme immunoassay (EIA) and Western blot assays.
  • Analysis of factors influencing screening program establishment, such as test characteristics, economics, and ethical considerations.

Related Experiment Videos

Main Results:

  • Commercial EIA combined with Western blot reliably classifies most serum samples as HIV-1 positive or negative.
  • Indeterminate results can often be resolved through retesting algorithms or future research-level diagnostic procedures.
  • Screening high-risk populations improves predictive accuracy, but confirmation testing is essential for all reactive sera.

Conclusions:

  • Implementing local HIV-1 screening programs can offer cost savings and flexibility for institutions.
  • Thorough technical and ethical considerations are paramount before initiating institutional HIV-1 screening programs.