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Related Experiment Video

Updated: Apr 24, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
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[Fluid resuscitation in hemorrhage].

M Roessler1, K Bode, M Bauer

  • 1Zentrum Anästhesiologie, Rettungs- und Intensivmedizin, Georg-August-Universität, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland, m.roessler@med.uni-goettingen.de.

Der Anaesthesist
|September 11, 2014
PubMed
Summary

Cautious fluid resuscitation with crystalloids may be sufficient for acute hemorrhage, avoiding aggressive fluid administration. Saline is not recommended; colloids like hydroxyethyl starch (HES) can be used cautiously in hypovolemic shock.

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Area of Science:

  • Emergency Medicine
  • Critical Care
  • Trauma Management

Context:

  • Fluid resuscitation strategies for acute hemorrhage remain debated.
  • Aggressive fluid administration lacks strong clinical trial evidence for improved survival.
  • Current guidelines recommend resuscitation upon hemodynamic instability.

Purpose:

  • To review current evidence and recommendations for fluid resuscitation in acute hemorrhage.
  • To discuss the potential risks of aggressive fluid resuscitation, including increased bleeding and dilutional coagulopathy.
  • To highlight the appropriate use of crystalloids and colloids, including hydroxyethyl starch (HES).

Summary:

  • Cautious crystalloid infusion may be initially sufficient, with saline discouraged.
  • Aggressive fluid resuscitation may exacerbate bleeding and worsen coagulopathy.
  • Damage control resuscitation requires careful monitoring of oxygen supply parameters.

Impact:

  • Informed clinical decision-making regarding fluid resuscitation in hemorrhage.
  • Potential reduction in adverse effects associated with aggressive fluid therapy.
  • Improved patient survival through optimized fluid management strategies.