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Published on: March 24, 2015
Interferon gamma (IFNγ) +874A/T gene polymorphism in South Indian ischemic stroke patients
Shehnaz Sultana1, Kolla K Venkata2, Penagaluru K Pranay3
1Bhagwan Mahavir Medical Research Centre, Hyderabad, AP, ; School of Human Genome Research & Genetic Disorders, Mahatma Gandhi National Institute of Research and Social Action, Hyderabad, AP, INDIA.
Background:
Ischemic stroke is a complex vascular and metabolic process resulting in neuronal death and progression with time. Cytokines play a role in immune response and also maintains the normal homeostatic environment of the central nervous system. IFN-γ is one of the key effector cytokines produced by NK and T cells that enhances microbicidal activity of macrophages and neutrophils.
Purpose:
As the association of IFNγ +874A/T gene polymorphism with stroke has not been investigated in Indian population, we wanted to evaluate the association of this polymorphism with ischemic stroke in a South Indian population.
Methods:
We genotyped 171 ischemic stroke patients and 153 age-matched control subjects.
Results:
Statistical analysis showed a significant association of TT homozygote with ischemic stroke (OR=1.9, 95% CI=1.05-3.43, p=0.03), while AA (OR= 0.84, 95% CI=0.54-1.31, p=0.46) and AT(OR=0.80, 95% CI=0.51-1.26, p=0.34) genotypes were not significantly associated. A and T allele frequencies in stroke were 58.78% and 41.22% as against 65.36% and 34.64% in control group, respectively, thus, suggesting no statistically significant differences in the A (OR=0.75, 95% CI=0.54-1.03, p=0.08) and T (OR=1.32, 95% CI=0.96- 1.82, p=0.08) allele frequencies between the two groups.
Conclusion:
We conclude that the IFN-γ +874 TT genotype is associated with the increased risk of ischemic stroke.
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