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Updated: Apr 24, 2026

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
Published on: July 31, 2013
Biologically inspired circuit model for simulation of glutamate gated ion channels of the postsynaptic membrane at
1Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.
Background:
Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.
Purpose:
The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glutamate gated ion channels of postsynaptic membrane at the synaptic cleft.
Method:
In this paper, Glutamate sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.
Result:
Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for excitatory action of synapses.
Conclusion:
This model can be used in neuro-bioengineering programs for simulation of binding activity and electrical activity of the postsynaptic region.
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