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Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects

Xinjun Li1, Zhong Yang2, Yi Zeng3

  • 1Department of Neurosurgery, Deyang People's Hospital, Deyang 618000, Sichuan Province, China.

Neural Regeneration Research
|September 11, 2014
PubMed

Insights

Neural tube defects in developing embryos are linked to cell cycle regulation. Retinoic acid exposure disrupts key cell cycle genes, impacting neural tube formation and potentially causing defects.

Area of Science:

  • Developmental Neurobiology
  • Molecular Biology

Background:

  • Normal neural tube formation relies on precise cell cycle and apoptosis regulation.
  • Previous research has implicated several genes in neural tube defects (NTDs).

Purpose of the Study:

  • To investigate the role of cell cycle and apoptosis-related genes in developmental neural tube defects.
  • To identify specific genes affected by retinoic acid during neural tube development.

Main Methods:

  • A rat model of developmental neural tube defects was created using retinoic acid administration.
  • Gene chip hybridization was employed to analyze gene expression profiles.

Main Results:

  • Gene expression analysis revealed involvement of genes in cell cycle, apoptosis, signal transduction, and metabolism.
  • Cell cycle-related genes were predominant among the differentially expressed genes.
  • Retinoic acid downregulated p57kip2, Cdk5, and Spin, while these genes are upregulated during normal neural tube formation.

Conclusions:

  • Cell cycle regulation is critical for preventing neural tube defects.
  • The genes p57kip2, Cdk5, and Spin are identified as potentially critical in the pathogenesis of neural tube defects.
Keywords:
cell cyclegene chipneural developmentneural regenerationneural tube defectsneurulationregenerationregulatory factorretinoic acid

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