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The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Role of calbindin-D28K in estrogen treatment for Parkinson's disease
Chunhua Wang1, Chao Jiang2, Honghua Yuan2
1Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Funing County People's Hospital, Yancheng 224400, Jiangsu Province, China.
Abstract:
Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.
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