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Updated: Apr 24, 2026
3D Kinematic Analysis for the Functional Evaluation in the Rat Model of Sciatic Nerve Crush Injury
Published on: February 12, 2020
L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
Ummü Zeynep Avsar1, Umit Avsar2, Ali Aydin3
1Department of Medical Education, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey.
Abstract:
Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.
