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Updated: Apr 24, 2026

Author Spotlight: Enhancing Cerebral Ischemia Research with a Simplified Rat Model
Published on: July 5, 2024
Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects
Qiuyun Tu1, Hui Cao2, Wei Zhong2
1Department of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
Abstract:
In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and superoxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects.
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