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Cervical adenoid Basal carcinoma: a case report
Asuman Argon1, Alper Sener2, Osman Zekioğlu2
1Clinic of Medical Pathology, Ministry of Health İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.
Balkan Medical Journal
|September 11, 2014
Summary
Adenoid basal carcinoma (ABC), a rare cervical cancer, can co-occur with squamous cell carcinoma. This case highlights the importance of recognizing ABC
Area of Science:
- Gynecologic Oncology
- Pathology
- Cancer Research
Background:
- Adenoid basal carcinoma (ABC) is an uncommon epithelial tumor of the cervix, representing about 1% of all cervical adenocarcinomas.
- While rare, ABC has been documented in association with other common cervical epithelial tumors.
- Accurate diagnosis is crucial due to potential co-occurrence with more aggressive malignancies.
Purpose of the Study:
- To report a case of adenoid basal carcinoma (ABC) co-existing with typical squamous cell carcinoma (SCC) of the cervix.
- To emphasize the diagnostic considerations for ABC, given its varied histological patterns and potential association with other cervical cancers.
Main Methods:
- Case presentation of a 54-year-old post-menopausal woman with vaginal bleeding.
- Histopathological examination revealing characteristic features of ABC and concurrent SCC.
- Surgical management including hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and omentectomy.
- Post-operative treatment with radiation therapy and chemotherapy for retroperitoneal metastasis.
Main Results:
- Histology confirmed the presence of both adenoid basal carcinoma (ABC) and large cell keratinized squamous cell carcinoma (SCC) in the cervix.
- The patient received multimodal treatment including surgery, radiation, and chemotherapy.
- No evidence of disease was observed 27 months post-diagnosis following treatment for retroperitoneal metastasis.
Conclusions:
- Adenoid basal carcinoma (ABC) is a rare cervical malignancy that requires careful histological evaluation to differentiate from tumors with similar morphology.
- The co-occurrence of ABC with more aggressive cancers like SCC underscores the need for comprehensive diagnostic assessment.
- Awareness of ABC's diverse histological presentations is essential for appropriate patient management and treatment planning in gynecologic oncology.