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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

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Published on: November 23, 2012

Spatial mapping of functional pelvic bone marrow using FLT PET.

Sarah M McGuire¹, Yusuf Menda, Laura L Boles Ponto

¹University of Iowa. sarah-mcguire@uiowa.edu.

Journal of Applied Clinical Medical Physics

|September 11, 2014

Summary

This study shows that specific bony regions on CT scans can represent active bone marrow, aiding radiation therapy planning when fluorodeoxyglucose-labeled thymidine (FLT) PET imaging is unavailable. Central pelvic bone regions show higher FLT uptake, indicating greater active bone marrow presence.

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Area of Science:

Nuclear Medicine
Radiation Oncology
Medical Imaging

Background:

Active bone marrow (ABM) is crucial in radiation therapy planning.
Fluorodeoxyglucose-labeled thymidine (FLT) Positron Emission Tomography (PET) imaging identifies ABM.
FLT PET is not always available, necessitating alternative methods for ABM identification.

Purpose of the Study:

To evaluate CT-defined bony landmarks as surrogates for ABM.
To compare CT-based regions with FLT PET imaging for ABM identification.
To develop CT-based methods for bone marrow sparing in radiation therapy planning.

Main Methods:

Whole-body FLT PET images were acquired from 18 subjects before chemoradiation.
FLT PET images were registered to subject-specific CT scans.
Seventeen pelvic bone regions were defined on CT; FLT uptake probability was calculated for each.

Main Results:

Four distinct groups of FLT uptake were identified within the 17 CT-defined regions.
Central pelvic regions (sacrum, iliac crests, L5 vertebra) showed significantly higher FLT uptake (p<0.05).
CT-defined regions can represent functional bone marrow identified by FLT PET.

Conclusions:

CT-defined bony landmarks can serve as surrogates for ABM in radiation therapy planning.
Central pelvic bone regions are more likely to contain active bone marrow.
FLT PET imaging offers superior spatial detail for complex treatment planning, especially when targets and ABM overlap.