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Dose differences between the three dose calculation algorithms in Leksell GammaPlan.

Andy Yuanguang Xu1, Jagdish Bhatnagar, Greg Bednarz

  • 1Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232. andyxu55@gmail.com.

Journal of Applied Clinical Medical Physics
|September 11, 2014
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Summary
This summary is machine-generated.

New GammaPlan dose calculation algorithms (TMR 10 and convolution) show dose differences compared to TMR classic. Convolution algorithm can result in up to 11.5% dose variation, requiring treatment prescription adjustments.

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Area of Science:

  • Medical Physics
  • Radiotherapy Physics
  • Radiation Oncology

Background:

  • GammaPlan software is used for treatment planning in Gamma Knife radiosurgery.
  • Previous versions utilized the TMR classic dose calculation algorithm.
  • Newer versions (v10) incorporate TMR 10 and convolution algorithms.

Purpose of the Study:

  • To evaluate dose differences between TMR 10 and convolution algorithms versus the TMR classic algorithm in GammaPlan v10.
  • To assess the impact of these dose calculation algorithm changes on treatment planning and prescription.

Main Methods:

  • Computed tomography (CT) images of a polystyrene phantom and a human head were acquired.
  • Treatment targets were defined with a prescription dose of 20 Gy to the 50% isodose line.
  • Treatment times were calculated using TMR 10, convolution, and TMR classic algorithms across various matrix positions and collimator sizes.

Main Results:

  • The TMR 10 algorithm showed minor dose variations (within ±2.5%) compared to TMR classic.
  • The convolution algorithm exhibited greater dose variations, reaching up to 11.5% in specific regions (e.g., superior frontal/parietal vertex) due to bone inhomogeneity.
  • Dose differences for the convolution algorithm ranged from 99.5% to 111.5% (Perfexion) and 99% to 109% (4C) of the calculated dose on the human head CT.

Conclusions:

  • The TMR 10 algorithm provides results comparable to TMR classic.
  • The convolution algorithm introduces significant dose variations, particularly in regions with bone, necessitating adjustments to treatment prescriptions.
  • Radiotherapy prescriptions based on TMR classic may require recalibration for the convolution algorithm to ensure accurate dose delivery.