Simulation of continuous solid phase synthesis: synthesis of methionine enkephalin and its analogs

The method of continuous solid phase synthesis, i.e., synthesis performed on a continual carrier, transferable from one synthetic compartment to another by means of a mechanical device, allows one to perform multiple synthetic steps simultaneously on different regions of the carrier. This procedure was tested on the synthesis of methionine enkephalin and its analogs. Products, obtained in reasonable yields, were fully characterized. Possible arrangements and the use of continuous solid phase synthesizers are discussed.