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Updated: Apr 24, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
Activation of Cre recombinase alone can induce complete tumor regression
Yulin Li1, Peter S Choi1, Stephanie C Casey1
1Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.
Abstract:
The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p53-/- mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors.
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