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Azithromycin cationic non-lecithoid nano/microparticles improve bioavailability and targeting efficiency.
Meng Zhong1, Yue Feng, Hong Liao
1Medicine Engineering Research Center, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Pharmaceutical Research
|September 12, 2014
Summary
This study developed novel azithromycin cationic non-lecithoid nano/microparticles, demonstrating significantly enhanced oral and intravenous bioavailability and improved lung targeting efficiency for azithromycin delivery.
Area of Science:
- Nanotechnology
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Azithromycin is a widely used antibiotic.
- Current drug delivery methods for azithromycin have limitations in bioavailability and targeted delivery.
- Niosomes offer a promising non-lecithoid alternative for drug encapsulation.
Purpose of the Study:
- To develop and evaluate azithromycin cationic non-lecithoid nano/microparticles (AMCNS).
- To achieve high bioavailability and efficient lung targeting of azithromycin.
- To explore oral and intravenous administration routes for AMCNS.
Main Methods:
- Cationic niosomes of varying sizes (AMCNS-S and AMCNS-L) were synthesized.
- Azithromycin (AM) was encapsulated within the niosomes.
- Bioavailability and lung targeting efficiency were assessed after oral and intravenous administration in comparison to free AM.
Main Results:
- AMCNS exhibited significantly enhanced oral (up to 273.19%) and intravenous (up to 163.50%) relative bioavailability compared to free AM.
- Intravenous administration of AMCNS resulted in substantial lung targeting efficiency, with lung AM concentrations 16-28 times higher than free AM at 12 hours.
- Consistent higher AM concentrations in the lungs compared to heart and kidney were observed with AMCNS.
Conclusions:
- Niosome-based azithromycin nanocarriers (AMCNS) demonstrate high bioavailability and effective lung targeting.
- This development offers a valuable strategy for antibacterial therapy using non-lecithoid niosomal applications.
- The study highlights the potential of AMCNS for improved azithromycin delivery.
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