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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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[Arthrosis: a scientometric analysis].

D Ohlendorf1, S Mayer, D Klingelhöfer

  • 1Institut für Arbeitsmedizin, Sozialmedizin und Umweltmedizin, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland, occup-med@uni-frankfurt.de.

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PubMed
Summary
This summary is machine-generated.

Arthrosis research is rapidly expanding, with most studies published recently. The United States leads global scientific output and collaboration in understanding this common cause of disability in older adults.

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Area of Science:

  • Rheumatology, orthopedics, and surgery are primary fields investigating arthrosis.
  • Scientometrics and bibliometrics are employed to analyze research trends.

Context:

  • Arthrosis is a leading cause of disability and reduced quality of life in industrialized nations.
  • Current therapeutic options for arthrosis are limited, and its underlying mechanisms remain incompletely understood.

Purpose:

  • To conduct a comprehensive scientometric analysis of global research on arthrosis.
  • To map research activities, geographical distribution, and collaborative networks in arthrosis studies.

Summary:

  • A review of 46,212 publications (1900-2013) revealed a significant increase in arthrosis research and citations over the last 25 years.
  • The United States dominates global research output and institutional collaboration in arthrosis.
  • Research activity shows a strong focus on rheumatology, orthopedics, and surgery.

Impact:

  • This study offers the first scientometric overview of arthrosis research, highlighting key geographical and collaborative patterns.
  • The findings indicate substantial scientific interest, particularly from North American and European researchers.
  • The continuous growth in research reflects the high prevalence and impact of arthrosis.